People who have to spend extended hours behind the wheel, are often being effected by drowsy driving. The major concern is for regular motorists and professional truck drivers. Provigil can certainly can keep them awake for a long period of time. This medicine is even used in the military to help pilots stay alert and sharp.
Falling asleep behind the wheel is one of the major causes for accidents. Although Provigil is not a panacea, it is for sure better than driving drowsy or speeding.
Provigil has been used for the treatment of post-chemotherapy cognitive impairment ( off-label). it is also known as a “chemo-brain”.
A number of studies have confirmed that Provigil helps reduce the problems with memory and attention, so scientists were hoping that Provigil might help breast cancer patients, who experience chemo-brain. In another study done on 68 patients it has been proven, that Provigil can help with memory problems in cancer patients.
Below is the successful case of the apathy treatment with Provigil.
The elderly man with dementia, has also suffered depression and apathy, and there was no response to the antidepressants treatment. Therefore he was prescribed Provigil, which action is different from antidepressants
The initial dose given was 50 mg, then it got increased to 200 mg a day during the 4 weeks period.
Apathy is a very common problem in people, and very often confused with depression. Therefore it is very important to differ these two, as the treatment which is usully prescribed for depression, if prescribed wrongly, can even increase apathy.
In this patient apathy has improved, which is proven that Provigil can be very useful in treatment of apathy.
Provigil is an increasingly popular wake-promoting drug used for the treatment of narcolepsy, but its precise mechanism of action is unknown. To determine potential pathways via which Provigil acts, we administered a range of doses of Provigil to rats, recorded sleep/wake activity, and studied the pattern of neuronal activation using Fos immunohistochemistry.
To contrast Provigil-induced wakefulness with spontaneous wakefulness, we administered Provigil at midnight, during the normal waking period of rats. To determine the influence of circadian phase or ambient light, we also injected Provigil at noon on a normal light/dark cycle or in constant darkness. We found that 75 mg/kg Provigil increased Fos immunoreactivity in the tuberomammillary nucleus (TMN) and in orexin (hypocretin) neurons of the perifornical area, two cell groups implicated in the regulation of wakefulness. This low dose of Provigil also increased the number of Fos-immunoreactive (Fos-IR) neurons in the lateral subdivision of the central nucleus of the amygdala.
