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Narcolepsy

Narcolepsy is a very common sleep disorder. It is caused by the inability of the brain to manage the sleep/awake cycle

Patients with this disorder experience an uncontrollable need for sleep, which can happen a number of times during the day.

People with that disorder usually fall asleep on a spot, and can remain asleep for an extended period of time. In some cases these sleepiness periods can last more than an hour.

These sleepiness periods can happen any minute,that is why Narcolepsy is potentially dangerous, if this person drives a car or performs any other dangerous activity.

The symptoms, common for narcolepsy are :excessive sleepiness, cataplexy ( loss of muscle tone), hallucinations and paralysis.

Narcolepsy affects about 1 in 200o people, and it can affect anybody, any age, race or social group.

The medication prescribed for this disorder is Provigil, which helps to reduce excessive sleepiness.

Interaction with other medicines

Provigil can increase or decrease liver activity, which is responsible for eliminating drugs from the body , so if liver activity changes, it could also decrease the effectiveness of other medicines you take. The body reaction should be very closely watched by the doctors, if taken with any other medicine.

In case you take an oral contraception, you should  consider an alternative method of contraception, as Provigil can decrease the effectiveness of that medicine.

There are some medicines which can increase the Provigil’s toxity. It is still not known about the interactions between Provigil and alcohol.

Provigil has a some side effects, which are not common, and only happen in about 5 % of patients, so Provigil is considered safe to use by the doctors.

Time-of-Day Variation in Task Performance

More than a century ago, it was reported that the capacity for doing mental work varies throughout the day. Several empirical studies have revealed time of day variations in performance, with subtle differences between different tasks. Similarly, in participants that are exposed to 36-60 h of sustained wakefulness in controlled laboratory (or constant routine) conditions, significant time of day variations in task performance are reported, with performance being worst for all tasks just after the time of core body temperature minimum (about 0400-0600 h). Subjective alertness levels are closely related to the time-of-day variation in task performance.

In the UK, as in many other countries, sleep-related vehicle accidents peak in the second half of the night (0200-0600 h), and also show a very modest rise in the mid afternoon (1400-1600 h).(10) The modest rise in accidents in the mid afternoon (which is small compared with the nocturnal rise) could reflect the post-lunch decrement in performance.(8) When variation in traffic density is taken into account, the likelihood of a sleep-related vehicle accident is 20 times higher at 0600 h than at 1000 h. Similarly, the risk of injury and fatality during the night shift is significantly greater than it is during traditional daytime working hours.(4,11) The cause of such accidents and injuries is often multifaceted, and the precise contribution of sleepiness is difficult to estimate.

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Sleep Disorders and Quality of Life

This article provides an overview of the daytime symptoms associated with the most common sleep disorders, namely insomnia, restless legs syndrome, obstructive sleep apnea syndrome and shift wake-sleep disorder.

Psychological and social dysfunction resulting from these sleep disturbances are explained and discussed in detail. Health-related quality of life is a concept that reflects the changes in diverse aspects of subjective wellbeing of the patients due to an illness.

Therefore, studies reporting quality-of-life issues associated with the aforementioned sleep disorders will also be presented. Finally, we review the limited data regarding the effects of treatment on quality-of-life outcomes.

Many patients with sleep disorders seek medical attention because of daytime symptoms or negative consequences of sleep disruption, which suggests that the night-time symptoms may be less bothersome than the daytime consequences of sleep problems.

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