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Provigil and Sleep Deprivation Research

Writer visits the United States Army Aeromedical Research Laboratory at Fort Rucker in Alabama… Tells about sleep deprivation research there by John and Lynn Caldwell… In ordinary circumstances, as the Caldwells’ research confirmed, sleep-deprived pilots make more errors and respond more slowly.

Dexedrine has been the standard treatment for narcolepsy, and it has had military applications as well: the United States Air Force supplied it to most air crews during the Persian Gulf War… Dexedrine interferes with normal sleep, leaving its users feeling hung over when they awaken. This so-called sleep inertia often prompts the user to take more pills, and a vicious cycle ensues. Provigil preserves normal “sleep architecture.”

Even as sleep disorders increase, firms are pushing their employees to disrupt their normal sleep patterns in order to provide services around the clock. Mentions that this may provide competitive advantages. The capability to resist the mental and physiological effects of sleep deprivation will fundamentally change current military concepts of “operational tempo” and contemporary orders of battle for the military services.

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Nuvigil is Differentiated from Provigil

The NDA is based on positive results of four double-blind, randomized, placebo-controlled studies of NUVIGIL in patients with excessive sleepiness associated with either narcolepsy, SWSD or OSA/HS. The data in this filing show that the primary endpoints of all studies were met and suggest that NUVIGIL is differentiated from PROVIGIL.

“This is the third of five FDA approvals that we will be pursuing over a 15-month time period,” said Dr. Paul Blake, Executive Vice President, Worldwide Clinical Research & Regulatory Affairs at Cephalon. “Cephalon is a pioneer in developing compounds for improving wakefulness, and this on- schedule filing allows us to reinforce our leadership position in the treatment of disorders of sleep and wakefulness,” added Dr. Blake.

Treatment of Insomnia

Once you and your doctor have ruled out any medical problems that may be causing your insomnia, you might try self-care methods. “Good sleep hygiene” refers to practices you can follow to help ensure adequate, quality sleep.

Stick to a regular bedtime schedule. Try to get out of bed at the same time each morning, even if it’s a weekend or holiday.

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Provigil for Sleep Disorders

Narcolepsy is caused by the loss of orexin-containing neurons in the hypothalamus, and a novel nonstimulant wakefulness-promoting drug, Provigil, alleviates excessive day-time sleepiness associated with the disorder.

The level of arousal is controlled by an intricate interplay between distinct wakefulness – and sleep-promoting nuclei situated in the hypothalamus and brainstem and the interconnections between the nuclei and the neurotransmitters involved have been mapped.

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