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Provigil for fatigue

This is still not exactly known how Provigil medicine works, but what’s the most important that it does, however it’s presumed that it is affecting dopamine that then is reducing the fatigue symptoms.

Fatigues can be different and therefore doses prescribed should be different, as this disorder can be caused by different issues – cognitive and physical.

On some occasions a cup of coffee can do the same job, which is to improve wakefulness. Provigil is brightening the emotions, elevating mood and increasing alertness.

Caffeine and Provigil

There has been a study done on 50 healthy volunteers that have been given the double dosage of the following medicine, and they had to stay awake for 48 hours

  • Provigil 200 mg
  • Caffeine 600 mg
  • Provigil 100 mg
  • Placebo
  • Provigil 400 mg

These people have been tested every hour to understand the response to the medicines. It’s been discovered, that caffeine 600 mg works similar to Provigil 400 mg. 200 mg of Provigil only helped to reverse fatigue.

Provigil and Treatment of Fatigue

Patients with partial response to anti-depressant therapy given for at least a 6-week period for a current major depressive episode (DSM-IV criteria) were enrolled in this 6-week, randomized, double-blind, placebo-controlled, parallel-group, multicenter study.

Patients received once-daily doses (100-400 mg) of Provigil or matching placebo as adjunct treatment to ongoing antidepressant therapy. The effects of Provigil were evaluated using the Hamilton Rating Scale for Depression (HAM-D), the Fatigue Severity Scale (FSS), the Epworth Sleepiness Scale (ESS), the Clinical Global Impression of Change (CGI-C), and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Adverse events were monitored throughout the study.

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Provigil for Fatigue

Provigil, like many drugs that we take for MS symptoms, seems to have a “we’re not sure how it works, but it does” factor. It is widely assumed that the drug works on one of the neurotransmitters (dopamine) in affecting fatigue.

Most of us know very well that these neurotransmitter chemicals live between our axons or nerve endings. They are the substance through which nerve firings occur. We also know that some of our damaged axons do not fire strongly enough to pass signals to the next due to demyelination.

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